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精东影业

Dr Felix Randow

  • College positions:
    Bye-Fellow
  • University positions:
    Group Leader MRC Laboratory of Molecular Biology (LMB)
    Director of Research 鈥淢olecular Immunology鈥, Department of Medicine
  • Subjects:

Degree(s)

Diploma Biochemistry, Humboldt University Berlin, Germany

PhD Cell Biology, Humboldt University Berlin, Germany

 

Research interests

I am a molecular immunologist interested in how individual human cells defend themselves against pathogens. Our work is inspired by the remarkable ability of unicellular organisms to resist infections entirely through cell-autonomous defences. We aim to identify fundamental principles of cell-autonomous immunity in mammals and how they work together with professional immune cells. By understanding these mechanisms, we hope to develop novel strategies for preventing and treating infectious diseases.

 

Teaching Interests

Immunology, Microbiology, Cell Biology

 

Awards and prizes

Wellcome Trust Senior Investigator Award 2021

Elected Fellow of the Academy of Medical Sciences 2019

Elected Member of EMBO 2018

 

Publications (selected)

Boyle, K., Ellison, C., Elliott, Schuschnig, Grimes, Dionne, Sasakawa, Munro, Martens, Randow, F. (2023). TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure. EMBO J 42, e113012

Otten, E.G., Werner, E., Crespillo-Casado, A., Boyle, K.B., Dharamdasani, V., Pathe, C., Santhanam, B., and Randow, F. (2021). Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection. Nature 594, 111鈥116.

Wandel, M.P., Kim, B.-H., Park, E.-S., Boyle, K.B., Nayak, K., Lagrange, B., Herod, A., Henry, T., Zilbauer, M., Rohde, J., MacMicking, J., Randow, F. (2020). Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol 21(8):1鈥12.

Ellison, C.J., Kukulski, W, Boyle, KB, Munro, S., Randow, F. (2020). Transbilayer movement of sphingomyelin precedes catastrophic breakage of enterobacteria-containing vacuoles. Current Biology 30: 1鈥10.

Ravenhill BJ, Boyle KB, von Muhlinen N, Ellison CJ, Masson GR, Otten EG, Foeglein A, Williams R, Randow F. (2019). The cargo receptor NDP52 initiates selective autophagy by recruiting the ULK complex to cytosol-invading bacteria. Mol Cell 74(2):320-329

Wandel, M., Pathe, C., Werner, E., Ellison, C., Boyle, K., Rohde, J., Randow, F. (2017). GBPs inhibit motility of Shigella flexneri but are targeted for degradation by the bacterial ubiquitin ligase IpaH9.8. Cell Host and Microbe 22, 5-7-518.

Noad, J., Malsburg, von der, A., Pathe, C., Michel, M.A., Komander, D., and Randow, F. (2017). LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-魏B. Nat. Microbiol 2, 17063.

Beale, R., Wise, H., Stuart, A., Ravenhill, B.J., Digard, P., and Randow, F. (2014). A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host and Microbe 15, 239鈥247.

Thurston, T.L.M., Wandel, M.P., Muhlinen, von, N., Foeglein, A., and Randow, F. (2012). Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 482, 414鈥418.

Thurston, T., Ryzhakov, G., Bloor, S., von Muhlinen, N., and Randow, F. (2009). The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 10, 1215-1221.